Does the Sealy Posturepedic Natural Origins work on an adjustable base?

Yes. This all-foam latex bed is rated for adjustable bases and bends smoothly at the head and foot, since it has no coils or rigid edge to fight the frame. The 5.5-inch comfort stack and dense HD foam core flex naturally. It also sits flat on a platform bed, a slatted base with gaps under 3 inches, or a solid foundation. Any firm, even surface supports it well.