How do you clean a bed frame?

Clean by material, and do it whenever you rotate the mattress. For wood, dust regularly and wipe with a slightly damp cloth, then dry immediately, since standing water damages the finish. Metal frames wipe down with a mild soapy cloth. Upholstered frames should be vacuumed to lift dust, then spot-cleaned with an appropriate fabric cleaner. Always get into the joints and slats, where dust and allergens collect most, and tighten any loose bolts while you are there.