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Adjustable Bed Base Friendly Mattresses With Antimicrobial Fabrics and Materials

Shop adjustable base friendly mattresses from Beautyrest, Serta, Sealy, Tempur-Pedic, Springwall, iComfort, and Stearns & Foster at National Mattress — 169+ models in memory foam, hybrid, latex, eurotop, and tight-top constructions from $59 to $6,640. Every mattress in this collection is manufacturer-verified to flex and articulate with an adjustable base without voiding the warranty. Available in Twin through King sizes with firmness levels from extra firm to plush, all built with CertiPUR-US® certified foams, including Canadian-made options. Free delivery is available, along with a 365-night sleep trial and 5–15 year warranty coverage.

Shop antimicrobial mattresses from Serta, Sealy, Beautyrest, Springwall, Evergreen, and iComfort at National Mattress, available in Single/Twin through King sizes across a range of budgets. Each mattress features bacteria-inhibiting fabric technologies like Serta® CoolFeel Fabric™ with Antimicrobial Fibre, Sealy® CleanProtect™, and Beautyrest® Antimicrobial Fibre Technology built directly into the cover and quilt layers. Available in eurotop, tight-top, memory foam, hybrid, and organic latex constructions across extra firm to plush comfort levels. All models are CertiPUR-US® certified, manufactured in Canadian factories, and ship free across Canada with a 365-night sleep trial.

Adjustable Bed Base Friendly Antimicrobial
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  • Serta Perfect Sleeper 10.5-inch firm tight-top mattress, white quilted top, charcoal-navy sides Serta Perfect Sleeper Premium Mattress Logo
    • 825 Edition Custom Support Coil System
    • CoolFeel Fabric™
    • Gel Band Support
    • Serta® Support Foam
    • PillowSoft® Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $1,399
    King SOLD OUT
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  • Serta Perfect Sleeper 11-inch plush pillow-top, white-blue burst quilting, charcoal sides Serta Perfect Sleeper Premium Mattress Logo
    • 825 Edition Custom Support Coil System
    • CoolFeel Fabric™
    • Gel Band Support
    • Serta® Support Foam
    • PillowSoft® Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $1,499
    King SOLD OUT
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  • Serta Perfect Sleeper 12-inch luxury-firm tight-top mattress, white blue-wave top, charcoal-navy sides Serta Perfect Sleeper Premium Mattress Logo
    • 850 Edition Custom Support Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® Support Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL In stock for fast delivery $742
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $1,799
    King SOLD OUT
    Online availability icon In-Stock Only 5 left!
    In-Store availability icon On Display:
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    M5H 2N1
  • Serta Perfect Sleeper 13.5-inch plush pillow-top mattress, white blue-burst top, charcoal-navy sides Serta Perfect Sleeper Premium Mattress Logo
    • 850 Edition Custom Support Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® Support Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL In stock for fast delivery $392
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $1,999
    King SOLD OUT
    Online availability icon In-Stock Only 4 left!
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  • Serta Perfect Sleeper 12-inch firm hybrid mattress, all-blue sunburst tight-top, navy sides Serta Perfect Sleeper Premium Mattress Logo
    • 1000 Series 3-Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Support Foam
    • Cool Twist® Gel Memory Foam
    • Hybrid Design
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $1,999
    King SOLD OUT
    Online availability icon Out Of Stock
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  • Serta Perfect Sleeper 13.5-inch firm pillow-top, light-blue burst quilting, charcoal sides Serta Perfect Sleeper Premium Mattress Logo
    • 850 Edition Custom Support Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® Support Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $1,999
    King SOLD OUT
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  • Serta Perfect Sleeper 14-inch plush hybrid, flat blue floral top, charcoal sides, navy piping Serta Perfect Sleeper Premium Mattress Logo
    • 1000 Series 3-Zoned Coil System
    • CoolFeel Fabric™
    • Serta® PillowSoft® Foam
    • Cool Twist® Gel Memory Foam
    • Hybrid Design
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL In stock for fast delivery $471
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $2,099
    King SOLD OUT
    Online availability icon In-Stock Only 3 left!
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  • Serta Perfect Sleeper Premium 14-inch extra-firm tight-top, deep-blue burst quilting, charcoal sides Serta Perfect Sleeper Premium Mattress Logo
    • 1000 Series 3-Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® Support Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $2,099
    King SOLD OUT
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  • Serta Perfect Sleeper Premium 14-inch medium-firm tight-top, blue wave quilting, charcoal sides Serta Perfect Sleeper Premium Mattress Logo
    • 1000 Series 3-Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® Support Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $2,099
    King SOLD OUT
    Online availability icon Out Of Stock
    In-Store availability icon On Display:
  • Serta Perfect Sleeper Premium 15-inch plush pillow-top, deep-blue floral quilting, charcoal sides Serta Perfect Sleeper Premium Mattress Logo
    • 1000 Series 3-Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® PillowSoft® Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL In stock for fast delivery $455
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $2,299
    King SOLD OUT
    Online availability icon In-Stock Only 2 left!
    In-Store availability icon On Display:
    Free delivery availability icon Free delivery to M5H 2N1 as soon as Tomorrow, Sep 24on select sizesfast delivery truck icon
    Pickup available icon Only Pickup available to
    M5H 2N1
  • Serta Perfect Sleeper Premium 15-inch firm pillow-top, deep-blue burst quilting, charcoal sides Serta Perfect Sleeper Premium Mattress Logo
    • 1000 Series 3-Zoned Coil System
    • CoolFeel Fabric™
    • Serta® Antimicrobial Fibre
    • Cool Twist® Gel Memory Foam
    • Serta® Support Foam
    • Designed and Made in Canada
    Single/Twin SOLD OUT
    Twin XL SOLD OUT
    Double/Full SOLD OUT
    Queen SOLD OUT
    Compare at $2,299
    King SOLD OUT
    Online availability icon Out Of Stock
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  • Beautyrest Quintessence 13-inch firm tight-top mattress, cream floral cover, charcoal woven side panel Beautyrest Quintessence Mattress Collection Logo
    • Beautyrest® T3 Pocketed Coil Technology
    • WinterCool™ Tri-Fiber with alpaca, cashmere, and silk.
    • WinterCool™ Sleep System with 4 distinct cooling technologies.
    • WinterCool™ Carbon Foam and GelTouch® Foam
    Twin XL In stock for fast delivery $709
    Queen SOLD OUT
    Compare at $2,999
    King SOLD OUT
    Online availability icon In-Stock Only 7 left!
    In-Store availability icon On Display:
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How Antimicrobial Mattress Fabrics Work and What to Look For

Antimicrobial mattress fabrics use silver-ion treatments, copper infusions, or engineered fibre technologies to inhibit the growth of odour-causing bacteria and common allergens on the sleep surface. At National Mattress, brands like Serta, Sealy, and Beautyrest each integrate proprietary antimicrobial systems, including Serta® CoolFeel Fabric™ with Antimicrobial Fibre, Sealy® CleanProtect™ Cover Technology, and Beautyrest® Antimicrobial Fibre Technology, directly into the mattress cover and quilt layers for continuous protection that does not wash out over time.

When comparing antimicrobial mattresses, consider what lies beneath the cover as well: hypoallergenic foams certified by CertiPUR-US® ensure the entire mattress, not just the surface, is free of harmful chemicals. Pairing an antimicrobial mattress with a quality mattress protector adds a washable barrier layer for maximum hygiene. All antimicrobial mattresses at National Mattress are manufactured in Canadian factories, ship with free delivery across Canada, and are backed by the manufacturer warranty terms.

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Built-In Antimicrobial Protection

Silver-ion and engineered fibre treatments in the cover and quilt layers actively inhibit bacteria and odour without washing out.

CertiPUR-US® Certified Foams

Every antimicrobial mattress uses independently tested foam free of ozone depleters, heavy metals, formaldehyde, and PBDEs.

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Cooling + Clean Sleep

Most models pair antimicrobial fabrics with cooling technology and breathable covers to manage moisture and temperature.

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Canadian-Made Quality

Manufactured in Canada with free delivery, a 365-night sleep trial, and price-match guarantee.

Frequently Asked Questions About Antimicrobial Mattresses

Do antimicrobial mattress fabrics actually work?
Yes. Technologies like Serta® Antimicrobial Fibre and Sealy® CleanProtect™ are engineered into the fabric at the manufacturing stage to inhibit bacterial growth on the mattress surface. They work continuously and do not diminish with use. Read our detailed breakdown on how antimicrobial fabrics work.
Are antimicrobial mattresses good for allergy sufferers?
Antimicrobial fabrics help reduce bacteria and odour on the sleep surface, but for full allergy protection, look for models also labelled hypoallergenic with CertiPUR-US® certified foams. Pairing with a mattress protector adds a washable dust-mite barrier for the most complete defence.
Which brands at National Mattress offer antimicrobial mattresses?
Six brands carry antimicrobial models: Serta and iComfort (CoolFeel Fabric™ + Antimicrobial Fibre), Sealy (CleanProtect™), Beautyrest (Antimicrobial Fibre Technology), Springwall, and Evergreen. Prices run from budget-friendly to luxury across a wide range of models.
Do I still need a mattress protector with an antimicrobial mattress?
A protector is still recommended. Antimicrobial fabrics inhibit bacteria on the surface, but a mattress protector adds waterproof and dust-mite-proof coverage that keeps your warranty valid and extends the mattress lifespan. See our complete protector guide for options.
What sizes and firmness levels are available in antimicrobial mattresses?
Antimicrobial mattresses at National Mattress are available in Single/Twin, Twin XL, Double/Full, Queen, and King sizes. Firmness options span extra firm, firm, medium, and plush across eurotop, tight-top, memory foam, hybrid, and organic latex constructions.
Do antimicrobial mattresses stop odour and keep the mattress fresh?
Antimicrobial treatments target the bacteria that cause mattress odour, helping the sleep surface stay fresher between cleanings. They are not a substitute for regular care, but they significantly slow bacterial buildup. Learn more in our guide on whether antimicrobial fabrics prevent mattress odour.

Find the Right Antimicrobial Mattress for Your Sleep Style

Our non-commissioned sleep experts can help you compare antimicrobial technologies across brands, no sales pressure, just honest guidance.

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